Silicon dioxide is a natural compound of silicon and oxygen found mostly in sand, silica has three main crystalline varieties. Do not attempt to take action without suitable protective equipment. Manufacture of aerosil and aeroperl pharma colloidal silicon dioxide 6 2. Call a poison center or doctorphysician if you feel unwell. Health hazard reactivity spectrum pharmacy products. In many parts of the world, silica is the major constituent of sand. Call 310 5168000 all chemicals may pose unknown hazards and should be used with caution. Silicon dioxide, synthetic amorphous silica, pyrogenic silica, hydrophobic fumed silica. All spectrum chemical nf, ep grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. Product and company identification product identifier. Appropriate engineering controls engineering measures to reduce exposure. Glasses are a class of materials made from silicon dioxide and other metal oxides.
A safety data sheet will be provided with your first delivery and with subsequent revisions. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Incompatible with fluoride, oxygen, difluoride, chlorine trifluoride. Silicon dioxide of small particle size may cause irritation and adverse health effects on the skin eyes and lungs silicosis. Identification of the substancemixture and of the companyundertaking. D2b this product contains trace amounts of 1, 3 butadiene, a chemical known to the state of california to cause cancer.
Before using colloidal silicon dioxide, inform your doctor about your current list of medications, over the counter products e. Definition colloidal silicon dioxide is a submicroscopic fumed silica prepared by the vaporphase hydrolysis of a silicon compound. Colloidal silicon dioxide, nf, ep is used both in the food and pharmaceutical industries as a powder flow helper in the production of tablets. Use fullface self contained breathing apparatus, impervious protective clothing. Silicon dioxide, single crystal substrate, optical grade, 99. Ingestion of this material can cause effects similar to those seen in clinical use including cholinergic crisis, charactertized by severe nausea, vomiting, salivation, sweating, slow heart rate, low blood pressure, muscles weakness, respiratory depression, syncope and convulsions. Fine particulate silica dust from quartz rock causes over a longterm progressive lung injury, silicosis. Safety data sheet according to 19072006ec, article 31 trade name. Get medical aid if irritation develops or persists. Preparation and characterization of silicon dioxide. Prosolv smcc silicified microcrystalline cellulose jrs pharma. Silica is another name for the chemical compound composed of silicon and. Sigmaaldrich material safety data sheet date printed. Silica is another name for silicon oxides, the most prevalent type being sio2.
At levasil colloidal silica we contribute to your success with innovations in silica chemistry. This product contains amorphous, colloidal or fumed silica. This product has been classified in accordance with the hazard criteria of the controlled products regulations and the msds contains all of the information required by those regulations. Wear selfcontained breathing apparatus and protective clothing to prevent contact with skin and eyes. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. Colloidal kaolin 2457 usp bc pharmaceutical colloidal kaolin, usp are used as as internal absorbent, diluent, filler and opacifier in pharmaceutical prepar ations. Silicon dioxide sio2, or silica, is known in nature as sand or quartz. Colloidal silicon dioxide is a submicroscopic fumed silica prepared by the vaporphase hydrolysis of a silicon compound. Safety data sheet creation date 15dec2011 revision date 30sep2019 revision number 5 1. This product has been classified in accordance with the hazard criteria of the cpr and the msds contains all of the information required by the cpr. Safety data sheet according to 19072006ec, article 31.
Colloidal silicon dioxide dried specimen in the crucible for the test for loss on ignition. Colloidal silicon dioxide 7631869 2315454 not listed not listed microcrystalline cellulose 9004346 2326749 not listed not listed additional information. Discover our broad product portfolio and reliable supply. The information in silicon dioxide e551 msds was obtained from current and reliable sources.
A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. Colloidal silicon dioxide 112945525 15 designates that a specific chemical identity andor percentage of composition has been withheld as a trade secret. Aerosil and aeroperl pharma colloidal silicon dioxide 3 the optimal glidant and beyond 2. Uses advised against food, drug, pesticide or biocidal. S1510, colloidal silicon dioxide, nf, ep table of contents product specification safety data sheet sds manufacturer certification of quality management system qms certification of current good manufacturing practices cgmp product bsetse statement product allergen statement product aflatoxin statement. Silicon dioxide cas 7631869 colloidal, highly dispersed emprove essential ph eur,nf,jp,e 551 find msds or sds, a coa, data sheets and more information.
This product has been classified in accordance with the hazard criteria of the canadian controlled products. Silicon dioxide, amorphous gel, 30% in isopropanol safety data sheet 08142015 en english us sds id. Colloidal silica polishing suspension safety data sheet. In veterinary applications, it functions as a topical and g. Colloidal silicon dioxide 7631869 2315454 not listed ingredient cas number eu einecselincs list eu classification %. Colloidal silicon dioxide daphnia magna tad ec50 48 hours 14 mgl 24 months rat. Aerosil colloidal silicon dioxide for pharmaceuticals. Section 6 accidental release measures procedures of personal precautions.
This material safety data sheet msds applies only to the material as packaged. Material safety data sheet according to regulation ec no. About 52% of these are oxide, 17% are electronics chemicals, and 7% are adsorbent. Silicon dioxide is not biodegradable, however the product itself will not affect environment. Colloidal silicon dioxide 7631869 2315454 titanium dioxide 463677 2366755. A wide variety of colloidal silicon dioxide options are available to you, such as grade standard. Silicon, 99% powder safety data sheet 06262015 en english us sds id. Firstaid measures inhalation remove victim to fresh air and keep at rest in a position comfortable for breathing. Silicon dioxide, amorphous gel, 30% in isopropanol safety. Prosolv smcc, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose mcc and colloidal silicon dioxide csd. Product is noncombustible hazardous combustion products. Impervious protective clothing is recommended if skin contact with drug product is possible and for bulk processing operations.
Carbon dioxide, dry chemical powder, or appropriate foam. Special remarks on reactivity special remarks on corrosivity polymerization will not occur. Search results for colloidal silicon dioxide at sigmaaldrich. Silicon dioxide msds, silicon dioxide materials safety. Silica is one of the most complex and most abundant families of materials, existing as a compound of several minerals and as synthetic product. If you experience drowsiness, dizziness, hypotension or a headache as sideeffects when using colloidal silicon dioxide medicine then it may not be safe to drive a vehicle or operate heavy machinery. A graphic model of aerosil pharma colloidal silicon dioxide aggregates. Chemtrec usa and canada emergency contact number 1800424.
Silica, colloidal anhydrous silicia colloidalis anhydrica aerosil contd. Silicon dioxide, chemically preparednot a pbt, vpvb substance as per the criteria of the. The terms hazardous and hazardous materials as used within this sds eu msd should be interpreted as defined by, and accordance with, the osha. Colloidal silicon dioxide is actually a commonly used filler product. Aerosil and aeroperl pharma colloidal silicon dioxide products. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Sigmaaldrich offers a number of silicon dioxide products. S1510, colloidal silicon dioxide, nf, ep spectrum chemical.
You might have seen it on a label or two and wondered what it is exactly. Proprietary ingredients indicated as hazardous have been assessed under standards for workplace safety. Colloidal silica based primary binder for investment casting manufacturer. Aerosil colloidal silicon dioxide for pharmaceuticals recommended products. However, the data is provided without any warranty, expressed or implied, regarding its correctness or accuracy. Aerosil and aeroperl pharma colloidal silicon dioxide.
Wear safety glasses or goggles if eye contact is possible. Chemtrec usa and canada emergency contact number 1. It is widely used in creams and lotions as a suspending agent and opacifier. Levasil colloidal silica a natural part of everyday life. Some health conditions may make you more susceptible to the sideeffects of the drug. Silicosis is a chronic disease of the lungs that is caused by the inhalation of silica dust over long period of time. Should the product become dried or misted such that inhalation of the material is possible, standard hygiene practices should be utilized to ensure that exposure to respirable particles is within the regulated limits. Also known as colloidal silica, this agent finds itself into many food and medicine products. Learn more on how colloidal silica differs from fumed and other types of silica. When ignited at for 2 hours, it contains not less than 99. Under our main product brand levasil colloidal silica and with our global network of manufacturing facilities, we provide our professional partners with a reliable supply of high and consistent quality colloidal silica. Conditions for safe storage, including any incompatibilities. Be sure to use an approvedcertified respirator or equivalent. Ac403731500 casno 7631869 synonyms silicon dioxide, synthetic amorphous silica, pyrogenic fumed amorphous silica recommended use laboratory chemicals.
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Dust can combine with air to form an explosive mixture. Silica, hydrophobic colloidal silica hydrophobica colloidalis definition colloidal silicon dioxide partly alkylated for hydrophobation. Pfizer inc believes that the information contained in this material safety data sheet is accurate.
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